An AFC matchup features the Tennessee Titans (0-1) visiting the Buffalo Bills (1-0) in the first half of a Monday Night Football doubleheader. Tennessee will try to build more rapport and continuity on the offensive side after they traded receiver A.J. Brown to the Philadelphia Eagles this offseason. On the flip side, Buffalo is one of the top 2023 Super Bowl contenders. The Bills’ roster is filled with plenty of talent and a star at quarterback with Josh Allen.

Kickoff from Highmark Stadium in Orchard Park, N.Y., is set for 7:15 p.m. ET. Buffalo is favored by 10 points in the latest Bills vs. Titans odds from Caesars Sportsbook, and the over/under is 47.5. Before making any Titans vs. Bills picks, you need to see the NFL predictions and betting advice from SportsLine’s advanced computer simulation model.

The model, which simulates every NFL game 10,000 times, is up more than $7,500 for $100 players on top-rated NFL picks since its inception. The model enters Week 2 of the 2022 NFL season on an incredible 139-98 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Bills vs. Titans and just locked in its picks and NFL predictions. You can head to SportsLine now to see the model’s picks. Now, here are several NFL odds and betting lines for Titans vs. Bills:

  • Bills vs. Titans spread: Buffalo -10
  • Bills vs. Titans over/under: 47.5 points
  • Bills vs. Titans money line: Tennessee +360, Buffalo -480
  • TEN: Titans are 8-2 ATS in their last 10 Monday games
  • BUF: Bills are 3-0-1 ATS in their last four home games
  • Bills vs. Titans picks: See picks here
Featured Game|Buffalo Bills vs. Tennessee Titans

Why the Bills can cover

Receiver Stefon Diggs is a true No. 1 option for the Bills’ passing attack. Diggs runs silky-smooth routes with hands like glue. The Maryland product has excellent concentration, consistently making outstanding grabs. Diggs offers strong YAC ability and has built a tight rapport with quarterback Josh Allen. In Week 1, the two-time Pro Bowler led the team with eight grabs for 122 yards with a touchdown.

Gabe Davis (questionable, ankle) will steps into a larger role as the No. 2 receiver for Buffalo. Davis is a physical, downfield threat with strong hands. The 2020 fourth-round pick knows how to gain separation and create a throwing window for Allen. Davis gashed the Rams’ defense for several big plays last week. He had four catches for 88 yards with a score, including three grabs for first downs.

Why the Titans can cover

Despite losing A.J. Brown this offseason, the Titans’ passing attack looked steady last week. They completed seven passes of 20-plus yards downfield, showing their willingness to take deep shots. Rookie receiver Treylon Burks can become a matchup nightmare since he can line up in multiple spots and has a unique combination of size (6-foot-2, 225 pounds) and speed. In his debut, the 2021 first-round pick snagged three receptions for 55 yards, or 18.3 yards per catch.

Receiver Robert Woods was acquired from Los Angeles this offseason. Woods has a mix of elusiveness and agility, allowing him to quickly get out his breaks. The USC product is a tough playmaker and a quality possession receiver. Woods has an opportunity to become a certified weapon for Tennessee’s passing game.

How to make Bills vs. Titans picks

SportsLine’s model is leaning Over on the total, with the teams projected to combine for 51 points. The model also says one side of the spread cashes in well over 50% of simulations.

By Toffee

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